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Disease Biology

From disease biology evidence to portfolio impact

Test scientific hypotheses by answering critical biological questions with explainable disease biology evidence built on human molecular and clinical data.

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CD
Crohn Disease Genetic
Target A
Target B
Target C
Target D
Target E
Target F
Target G
Target H
Target I
Ulcerative …
Rheum. Art…
COPD
Scleroderma
Alopecia Ar…
Relevant Disease Models Immune disease
CD
Crohn Disease Colon
UC
Ulcerative Colitis Ileum
PM
Celiac Disease Duodenum
CD
Crohn Disease Genetic
Meta-Analysis of 8 Datasets Differentially expressed genes in disease vs healthy groups | disease (n=308) vs healthy (n=183)
Volcano plot of differentially expressed genes
CD
Crohn Disease Genetic
Key Cells
macrophage neutrophil regulatory T cell T-helper 1 cell fibroblast
Key Pathways
Chemokine signaling pathway NF-kappa B signaling IL-17 signaling pathway Inflammatory bowel disease
Clinical Scores
Rutgeert's_score SES_score
Trusted by Industry Leaders

Used at increasing scale by top pharma companies

“At Sanofi, our drug discovery strategy is driven by precision medicine. We seek to describe diseases at the molecular and cellular level to understand the causes underpinning different patient responses to treatments, and to ultimately match the right medicine to the right patient. We are pleased to expand our collaboration with CytoReason and look forward to applying insights from this collaboration as we work to develop new treatments for patients with IBD.”

Emanuele de Rinaldis - Sanofi, Global Head of Target, Disease & Systems Biology

Disease Biology Evidence Explorer

Explore the computed disease biology evidence behind your most important portfolio decisions

See how CytoReason generates computed disease biology evidence to help test scientific hypotheses
and answer the critical biological questions behind each portfolio decision.

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Decision Enabled

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Example · Biological Questions
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Example · CytoReason Disease Biology Evidence
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Portfolio Impact at Scale

Portfolio impact at scale

Leading pharmaceutical and biotechnology teams use CytoReason's disease biology evidence every day to inform decisions across their highest-priority R&D programs.

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Learn About Our Approach

Why CytoReason is uniquely able to generate
disease biology evidence

CytoReason combines human molecular and clinical data, computational disease biology, and scientific expertise to generate explainable disease biology evidence at scale.

Explore Our Approach →

Ready to inform your next portfolio decision?

See how CytoReason can help your team answer critical biological questions and
generate disease biology evidence for your highest-priority R&D programs.

Connect with our team →